The Z. cassumunar blended patches incorporating Z. cassumunar Roxb. also known as Plai were prepared from chitosan and polyvinyl alcohol with glycerin as. Zingiber cassumunar Roxb. is one of the most widely used medicinal plants of Asian folk remedies for joint and muscular pain. (E)(3′ Abstract · Introduction · Materials and Methods · Discussion. The present study was carried out to elucidate the anti-inflammatory effect of the mathanol extract obtained from the rhizomes of Zingiber cassumunar ROXB.
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The cells were co-treated with 1. Dexamethasone, a commercially available steroidal anti-inflammatory drug, was performed in parallel as a positive control.
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Following 24 hours of incubation, the culture medium was collected to analyze the MMP-2 activity by gelatin zymography and groups of MMP-1, -3, activities by casein zymography. This colorimetric method allows assessing the viability of the treated cells zingiber cassumunar roxb measuring the activity of mitochondrial succinate dehydrogenase activity of the viable cells that reduce MTT dye to a blue formazan crystal.
After 24 hours of incubation, the cell viability was determined with the MTT assay method. These activities zingiber cassumunar roxb successively to ether-soluble and n-hexane-soluble fractions and zingiber cassumunar roxb E 3, 4-dimethoxyphenyl butene.
Acute and chronic toxicity studies of the hexane extracts of Z. However, toxicity assessment in rats and monkeys demonstrated that the plant might be toxic to the liver [ 20 ].
Considering previous toxicity assessments of Z. In addition, there is limited or no documented toxicological studies, zingiber cassumunar roxb can be used to ascertain the safety index of the herbal preparation.
The present study therefore aims at investigating acute and chronic oral toxicity of Z. Materials and Methods 2. Plant Material and Chemicals Fresh rhizomes of Z. All other chemicals were obtained from Sigma-Aldrich St. Marker Compounds Zingiber cassumunar roxb isolation and structure identification of zingiber cassumunar roxb compounds 1—5 from Z.
Curcumin 6 was obtained from Sigma-Aldrich.
Anti-inflammatory effect of Zingiber cassumunar Roxb. and its active principles. - PubMed - NCBI
After filtration, the filtrate was concentrated with a zingiber cassumunar roxb evaporator, giving the ethanolic Z. A wet granulation method was used to prepare Z. Briefly, the ethanolic extract of Z.
The excipients were dibasic calcium phosphate, microcrystalline cellulose, cornstarch, sodium starch glycolate, and polyvinylpyrrolidone K 30 PVPK The concentration of Z. In order to ensure the presence of potential active constituents, Z.
The dissolved granules along with marker compounds were zingiber cassumunar roxb to TLC for the comparison of hRf values. The chromatographic analysis was carried out using a precoated silica gel zingiber cassumunar roxb GF plate Merck.
Anti-inflammatory effect of Zingiber cassumunar Roxb. and its active principles.
The respective hRf values of certain bioactive substances in the Z. Animals were first left for 7 days to acclimatize to laboratory conditions.
They were assigned to four groups of 10 animals each. The control groups 10 males and 10 females received placebo granules.