GELLING AGENTS IN PHARMACEUTICALS EPUB DOWNLOAD

Gels are semisolid, jelly-like pharmaceutical formulations that range widely in viscosity. They are made from gelling agents that undergo a high degree of cross linking or association when dissolved or dispersed in the appropriate media. Types of gelling agents: There are a variety of polymers acting as gelling agents[35,36]. a. Natural polymers-Proteins like gelatin, casein, collagen, egg whites, polysaccharides like guar gum, acacia, tragacanth, bug bean gum, pectin, starch, xanthan gum, dextran, succinoglucon etc (Tables 2 and 3). Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, 51, Deh Tor, gelling agent and a solvent in which the drug molecules are embedded or.


GELLING AGENTS IN PHARMACEUTICALS EPUB DOWNLOAD

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GELLING AGENTS IN PHARMACEUTICALS EPUB DOWNLOAD


It is gelling agents in pharmaceuticals further object of certain embodiments of the invention to provide a method of manufacturing an oral dosage form of an opioid analgesic such that it has less abuse potential. These objects and others are achieved by the present invention, which is directed in part to an oral dosage form comprising an opioid analgesic; and at least one aversive agent for reducing the abuse of the opioid analgesic.

In gelling agents in pharmaceuticals embodiments of the present invention, the dosage form comprises an aversive agent such as a bittering agent to discourage an abuser from tampering with the dosage form and thereafter inhaling or swallowing the tampered dosage form.

Carboxymethyl mungbean starch as a new pharmaceutical gelling agent for topical preparation.

In certain embodiments of the present invention, the dosage form comprises gelling agents in pharmaceuticals aversive gelling agents in pharmaceuticals such as an irritant to discourage an abuser from tampering with the dosage form and thereafter inhaling, injecting, or swallowing the tampered dosage form.

In certain preferred embodiments, when the dosage form is tampered with and exposed to a small amount e. Upon the addition of the aqueous liquid, the tampered dosage form preferably becomes thick and viscous, rendering it unsuitable for injection.

In certain embodiments, the gelling agent is present in such an amount in the dosage form that attempts at evaporation by the application of heat to an aqueous mixture of the dosage form in an effort to produce a higher concentration of the therapeutic agent, produces a highly viscous substance unsuitable for injection.

Stability and drug release profiles of CMMS and commercial gelling agents were compared.

The results supported the potential use of CMMS as a new, effective gelling agent for topical gel preparation. The immediate release oral dosage form of claim 1, wherein the viscosity is attained when the dosage form is subject to tampering by dissolution in from about 1 gelling agents in pharmaceuticals about 3 ml of aqueous liquid.

Carboxymethyl mungbean starch as a new pharmaceutical gelling agent for topical preparation.

The immediate release oral dosage form of claim 1, wherein the solubilized mixture has a viscosity of at least about 60 cP. The immediate release oral dosage form of claim 1, further comprising an additional drug selected from the group consisting of an NSAID, a COX-2inhibitor, acetaminophen, aspirin, an NMDA receptor antanalgesic, a drug that blocks a major intracellular consequence of NMDA-receptor activation, an antitussive, an expectorant, a decongestant, an antihistamine and mixtures thereof.

The immediate release oral dosage form gelling agents in pharmaceuticals claim 1, wherein the solubilized mixture has a viscosity of cP or greater. The immediate release oral dosage form of claim 1, wherein the solubilized mixture has a viscosity of from cP to 5, cP. A method of preventing abuse of an oral immediate release dosage form comprising: Typically, a gelling agents in pharmaceuticals dose of an opioid analgesic is more potent when administered parenterally as compared to the same dose administered orally.

Viscosity and X-ray diffraction results indicated a good compatibility between CMMS and the acidic piroxicam.

Pharmaceutical formulation containing gelling agent - Purdue Pharma L.P.

No precipitation of piroxicam or phase separation was observed during a stability test. Opioid antagonists have been combined with certain opioid agonists in order to deter the parenteral abuse of opioid agonists.

GELLING AGENTS IN PHARMACEUTICALS EPUB DOWNLOAD

Purdue Pharma EP currently markets sustained-release oxycodone in dosage forms containing 10, 20, 40, and 80 mg oxycodone hydrochloride under the tradename OxyContin.

However, there still exists a need for a safe and gelling agents in pharmaceuticals treatment of pain with opioid analgesic dosage forms which are less subject to abuse than current therapies.

All documents cited herein, including the foregoing, art incorporated by reference in their entireties for all purposes.

GELLING AGENTS IN PHARMACEUTICALS EPUB DOWNLOAD

It is an object of certain embodiments of the invention to provide an oral dosage form of an opioid analgesic which is subject to less intranasal abuse than other dosage forms.

It is an object of certain embodiments of the invention to provide an oral dosage form of an opioid analgesic which is subject to less oral abuse than other dosage gelling agents in pharmaceuticals.

It is a further object of certain embodiments of the invention to provide an oral gelling agents in pharmaceuticals form of an opioid analgesic which is subject to less diversion than other dosage forms.